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Hello, my name is Miguel. I am a biologist with great interest in understanding life from a quantitative and systematic perspective. My current efforts are focused on advancing the understanding of RNA modifications, working in the development of technologies to detect and quantify different moieties across whole transcriptomes.

I am currently an academic collaborator at the Schwartz Lab of the Weizmann Institute of Science, from which I recently graduated as a PhD and I am looking for a prospective lab to continue my work as a postdoctoral fellow.

In the Schwartz lab, we work in the field of Epitranscriptomics, a booming research field that deals with the biochemical modifications of RNA molecules of all living organisms and even viruses. My previous work revolved around N6-methyladenosine (m6A). m6A is a highly abundant mRNA modification present in all eukaryotes, and it has recently received attention as a potential therapeutic target for treating diseases such as Cancer, Osteoporosis, Obesity, and Diabetes. At the SchwartzLab, we developed a methodology, that is able to detect and quantify m6A in a high-throughput, single-nucleotide, and antibody-independent manner. Using this new technology we uncovered a code that dictates m6A deposition across the transcriptomes of mouse and yeast, one of our main conclusions is that m6A deposition is strongly coded in the RNA sequence of each gene.

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Miguel's GitHub contributions in the last year

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