About
Hello, my name is Miguel. I am a biologist with great interest in understanding life from a quantitative and systematic perspective. My current efforts are focused on advancing the understanding of RNA modifications, working in the development of technologies to detect and quantify different moieties across whole transcriptomes.
I am currently an academic collaborator at the Schwartz Lab of the Weizmann Institute of Science, from which I recently graduated as a PhD and I am looking for a prospective lab to continue my work as a postdoctoral fellow.
In the Schwartz lab, we work in the field of Epitranscriptomics, a booming research field that deals with the biochemical modifications of RNA molecules of all living organisms and even viruses. My previous work revolved around N6-methyladenosine (m6A). m6A is a highly abundant mRNA modification present in all eukaryotes, and it has recently received attention as a potential therapeutic target for treating diseases such as Cancer, Osteoporosis, Obesity, and Diabetes. At the SchwartzLab, we developed a methodology, that is able to detect and quantify m6A in a high-throughput, single-nucleotide, and antibody-independent manner. Using this new technology we uncovered a code that dictates m6A deposition across the transcriptomes of mouse and yeast, one of our main conclusions is that m6A deposition is strongly coded in the RNA sequence of each gene.
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Status Updates
- 14-May-2024 - Published preprint: Dierks, D. et al., Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism.
- 21-March-2024 - Published work: Garcia-Campos M.A. & Schwartz S. txtools: an R package facilitating analysis of RNA modifications, structures, and interactions.
- 15-February-2024 - Published work: Shachar, R. et al., Dissecting the sequence and structural determinants guiding m6A deposition and evolution via inter- and intra-species hybrids.
- 26-August-2023 - Published preprint: Garcia-Campos, M. A. & Schwartz, S. txtools: an R package facilitating analysis of RNA modifications, structures, and interactions. bioRxiv, 2023-08.
- 06-December-2022 - Oral Presentation: “STORM-seq: a technology for simultaneous sequencing of twelve (and more) rRNA modifications”. Slides. RNA biology 2022 Cold Spring Harbor-Asia, Awaji, Japan.
- 18-March-2022 - Lecture: MAZTER-seq, el código de m6A de levadura a mamíferos. Slides. Curso preparación para docentes 2022-1, Universidad Técnica de Ambato, Ecuador.
- 01-March-2022 - Postdoctoral fellowship: Continue my work at the Schwartz Lab.
- 17-February-2022 - PhD thesis defense: “Towards single-nucleotide resolution maps of RNA modifications”
- 03-September-2021 - Published work: Dierks, et al., Multiplexed profiling facilitates robust m6A quantification at site, gene and sample resolution.
- 21-June-2021 - Award: Lady Anne Chain Memorial Prize for academic excellence during Ph.D. studies at the Weizmann Institute of Science. Video.
- 25-October-2020 - Teaching: Principles and practice of large scale data analysis using R 2021-1 course starts. Recordings available for WIS students and auditors.
- 16-October-2020 - Published work: González, et al., “Tolerance to Oxidative Stress in Budding Yeast by Heterologous Expression of Catalases A and T from Debaryomyces hansenii”.
- 17-February-2020 - Poster: ILANIT-2020:; BioTrivia 1st place Winner! :) Video.
- 24-October-2019 - Short talk: “MAZTER-seq and the m6A code” Slides, 2019 RNA Biology and Processing meeting in memory of Prof. Yossi Sperling, Tel Aviv, Israel.
- 05-August-2019 - Media coverage: Sneaky RNA Tag Rendered Visible, article covering the publication of our work developing MAZTER-seq.
- 27-June-2019 - Published work: Garcia-Campos, et al. “Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling.” Cell (2019).
- 4-March-2019 - Published preprint: Garcia-Campos, et al. “Deciphering the’m6A code’via quantitative profiling of m6A at single-nucleotide resolution.” BioRxiv (2019): 571679.